Ketoprofen

Name: Ketoprofen

Trade Name(s): Anafen

Preparation:  Anafen injection is supplied in two concentrations, 10 mg/ml for small animals and 100 mg/ml for large animals, in multidose vials.  It is also available as 5mg, 10mg and 20mg tablets.

Description: Ketoprofen is a nonsteroldal anti-inflammatory (NSAID) and analgesic drug of the propionic acid subclass of carboxylic acid derivatives.  Other propionic acid derivative NSAIDS Include ibuprofen, naproxen and fenoprofen.

Availability: Ketoprofen is a prescription drug

Indications: Ketoprofen has potent anti-inflammatory activity against acute, subacute and chronic infflammation, and is useful for management of post-surgical pain, and for relieving chronic pain (e.g., arthritis, etc.) and for the symptomatic treatment of fever.

Dosage: Consult the laboratory animal veterinarian.

Routes of administration: Ketoprofen can be injected by intramuscular, intravenous or subcutaneous routes, or given orally (tablets).

Duration of action: Ketoprofen has a long duration of action and can usually be administered once a day.  Onset of activity occurs within 1/2 hour after parenteral injection and within 1 hour of oral administration.

Mechanism of analgesic action: The primary mechanism of action is through inhibition of prostaglandin synthesis by interfering with the cyclo-oxygenase pathway of arachidonic acid metabolism.

Clinical pharmacology: Ketoprofen is propionic derivative; 2-(3-benzoyl phenyl) propionic acid.  Other propionic acid derivative NSAIDS include ibuprofen.  Like other NSAIDs, ketoprofen produces analgesic, anti-inflammatory, and antipyretic effects.

Notes:  Like other NSAIDs, ketoprofen may cause irritation of the gastrointestinal tract, and should not be used if there is impaired liver and/or kidney function, or coagulation disorders.

References:

Compendium of Veterinary Products, 6th Ed.  1999.  Canadian Animal Health Institute. North American Compendiums, Hensall, Ontario

Pain Management in Animals.  2000  Flecknell P and Waterman-Pearson A (eds). WB Saunders, London  184pp.

Laboratory Animal Anesthesia.  1996.  Flecknell P.  Academic Press, London.  274 pp.