Trade Name(s): Anafen
Preparation: Anafen injection is supplied in two concentrations, 10 mg/ml for small animals and 100 mg/ml for large animals, in multidose vials. It is also available as 5mg, 10mg and 20mg tablets.
Description: Ketoprofen is a nonsteroldal anti-inflammatory (NSAID) and analgesic drug of the propionic acid subclass of carboxylic acid derivatives. Other propionic acid derivative NSAIDS Include ibuprofen, naproxen and fenoprofen.
Availability: Ketoprofen is a prescription drug
Indications: Ketoprofen has potent anti-inflammatory activity against acute, subacute and chronic infflammation, and is useful for management of post-surgical pain, and for relieving chronic pain (e.g., arthritis, etc.) and for the symptomatic treatment of fever.
Dosage: Consult the laboratory animal veterinarian.
Routes of administration: Ketoprofen can be injected by intramuscular, intravenous or subcutaneous routes, or given orally (tablets).
Duration of action: Ketoprofen has a long duration of action and can usually be administered once a day. Onset of activity occurs within 1/2 hour after parenteral injection and within 1 hour of oral administration.
Mechanism of analgesic action: The primary mechanism of action is through inhibition of prostaglandin synthesis by interfering with the cyclo-oxygenase pathway of arachidonic acid metabolism.
Clinical pharmacology: Ketoprofen is propionic derivative; 2-(3-benzoyl phenyl) propionic acid. Other propionic acid derivative NSAIDS include ibuprofen. Like other NSAIDs, ketoprofen produces analgesic, anti-inflammatory, and antipyretic effects.
Notes: Like other NSAIDs, ketoprofen may cause irritation of the gastrointestinal tract, and should not be used if there is impaired liver and/or kidney function, or coagulation disorders.
Compendium of Veterinary Products, 6th Ed. 1999. Canadian Animal Health Institute. North American Compendiums, Hensall, Ontario
Pain Management in Animals. 2000 Flecknell P and Waterman-Pearson A (eds). WB Saunders, London 184pp.
Laboratory Animal Anesthesia. 1996. Flecknell P. Academic Press, London. 274 pp.