EMLA

Name: EMLA

Trade Name(s): EMLA Cream

Preparation: EMLA (Eutectic Mixture of Local Anesthetics) is a eutectic mixture of lidocaine and prilocaine bases, in 30 gm tubes.  Each gram of cream contains 25 mg lidocaine and 25 mg prilocaine as an oil/water emulsion.

Description:  An emulsion of two local anesthetics.

Availability:

Indications: For use as a topical anesthetic for skin.

Dosage: Cream is applied to area of skin at least 30 minute and ideally one hour before analgesia is needed at the site.  Cream is left in contact with the skin for 5-10 minutes.

Routes of administration: Apply topically on the skin in the area where analgesia is required.

Duration of action: Local analgesia of intact skin is achieved after a 60­ minute application under an occlusive dressing.  Analgesia increases up to 120 minutes. The duration of analgesia after I-2 hour application is at least 2 hours and decreases after 5 hours.

Mechanism of analgesic action: Lidocaine and prilocaine are amide-type local anesthetic agents. They stabilize the neuronal membrane preventing the initiation and conduction of nerve impulses

Clinical pharmacology: Lidocaine and prilocaine are amide-type local anesthetic agents. They stabilize the neuronal membrane preventing the initiation and conduction of nerve impulses.

Physiological effects:

         Cardiovascular:

         Respiratory:

Drug Interactions:

Notes:

References

Pain Management in Animals.  2000  Flecknell P and Waterman-Pearson A (eds). WB Saunders, London  184pp

Laboratory Animal Anesthesia.  1996.  Flecknell P.  Academic Press, London.  274 pp.

Compendium of Pharmaceuticals and Specialities 36th Ed.  2001.  Canadian Pharmacists Association, Ottawa, Ontario