FAQ CCAC policy statement on: scientific merit and ethical review of animal-based research

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GENERAL CONSIDERATIONS
  1. How are research proposals and animal use protocols linked? arrow
  2. Who is responsible for ensuring that research has scientific merit? arrow
  3. Who is responsible for ensuring that animal-based methods are appropriate for the proposed work? arrow
  4. Is animal use typically described in research proposals? arrow
APPLICATION OF SCIENTIFIC MERIT REVIEW REQUIREMENTS
  1. What kinds of projects need to be reviewed for scientific merit? arrow
  2. Does peer review of scientific merit need to be conducted on a yearly basis? arrow
  3. Who should determine whether a new study can be considered part of an existing research program? arrow
  4. Do pilot studies require peer review? arrow
  5. How should scientific merit be addressed for collaborative animal-based projects? arrow
  6. How should scientific merit be addressed for organizations with several sites, research stations or centres? arrow
MECHANISMS FOR DETERMINING SCIENTIFIC MERIT IN DIFFERENT TYPES OF ORGANIZATIONS
  1. How can academic institutions determine the scientific merit of basic or applied research? arrow
  2. How can government institutions determine the scientific merit of basic or applied research? arrow
  3. How can private organizations determine the scientific merit of basic or applied research? arrow
THE INSTITUTIONAL SCIENTIFIC MERIT REVIEW PROCESS
  1. What tools can be useful in establishing organizational peer review processes? arrow
  2. What happens when a principal investigator’s work is funded through a source that does not appear to have a recognized peer review mechanism? arrow
  3. What are the most important criteria in selecting reviewers? arrow
  4. How can these criteria be met? arrow
  5. Who selects peer reviewers? arrow
  6. Can the ACC coordinator be involved in selecting peer reviewers? arrow
  7. What documents should be sent to reviewers? Is a completed animal use protocol form enough? arrow
  8. What should reviewers provide as evaluations of scientific merit? arrow
RESPONSIBILITIES OF PRINCIPAL INVESTIGATORS
  1. What can principal investigators do to help the ACC understand their proposed animal-based methods? arrow
  2. Can principal investigators forward information from grant proposals and information received through scientific merit reviews to ACCs, in order to facilitate ACC review of animal use protocols? arrow
RESPONSIBILITIES OF THE ACC
  1. What can the ACC do to ensure that the proposed animal-based methods are appropriate for the work being planned, and that the Three Rs have been carefully considered and applied? arrow