The CCAC publishes guidelines documents on the ethical use and care of animals in science. All CCAC guidelines are based on scientific evidence and have undergone extensive peer review. For details on how CCAC guidelines are developed, please see Development of Peer-Based Guidelines.
For information on other topics, see the CCAC's Guide to the Care and Use of Experimental Animals
Guide to the Care and Use of Experimental Animals, vol.2 (1984)
This guide is currently under revision. Until the revision process is complete, the individual chapters still in use and links to best practice information are listed below.
Some hyperlinks within these documents may no longer be valid. Please contact us at if details are required.
Assessments of institutional animal care and use programs are based on CCAC guidelines documents, CCAC policy statements and other relevant documents. Additional information that is provided alongside guidelines documents, such as species-specific recommendations, and information provided on the CCAC Three Rs Microsite is intended to support the implementation of the guidelines, but is not used as a basis for recommendations made in CCAC assessment reports.
Guidelines are intended to provide assistance in the implementation of best practices and the achievement of Russell and Burch’s Three Rs for use of animals in science. The CCAC recognizes that guidelines with the term ‘should’ may be subject to interpretation by properly constituted animal care committees (ACCs), and that in some cases, an ACC may accept a lesser standard of practice on the basis of adequate evidence and in keeping with the principles of the Three Rs. This discretion is not extended to any other parties. Where regulatory requirements are involved or where the CCAC considers that no lower standard of practice could be accepted, the term ‘must’ has been used. (CCAC Guidelines Committee, March 8, 2008)