Alternative Test Methods Table: Validation & Regulatory Status
Introduction
The Alternative
Test Methods Table aims to provide a resource for
investigators and regulators on the validation and
regulatory status of alternatives to animal-based
regulatory test methods. We have tried to include only
those methods which have at least reached the stage of
being considered for a validation study (i.e. method
development, pre-validation, and method [protocol]
standardization are complete).
Please be aware
that this table is subject to continual review and
updates. Each alternative method indicates when the
information for that particular method was last reviewed
or updated by the CCAC. While all attempts have been
made to provide accurate information and references, the
CCAC recognizes that, due to the wide scope of the
project, some errors and omissions may have been missed
in our review process. Therefore, we invite you to
contact us at
ThreeRs@ccac.ca with any corrections or additions to the table,
or any other comments or questions. It is our hope that
this interaction with those involved in regulatory
testing will continually improve and strengthen the
usefulness of the Alternative Test Methods Table.
Using the Table
The methods are
grouped by category of use (i.e. carcinogenicity, skin
irritation, etc.) and then further organized by the name
of the “conventional test method” (i.e. the test that
the alternative proposes to supplant). For each
conventional test method, you will find descriptions of
possible alternative test methods, information about the
validation and regulatory status of the alternative and
the potential effect on animal use (i.e. whether the
alternative test provides a replacement, reduction or
refinement to the conventional test method).
A list of references related to each alternative
method can be found by clicking on the
Details and references link associated with that method.
Test method categories
List of Abbreviations
Acronyms have been used extensively in the Alternative Test Methods
Table. A list of the most commonly used acronyms can be
accessed by clicking on the
List of Abbreviations link located below the table
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