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CCAC guidelines on: choosing an appropriate endpoint in experiments using animals for research, teaching and testing

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The CCAC guidelines on: choosing an appropriate endpoint in experiments using animals for research, teaching and testing were developed by the ad hoc subcommittee on endpoints of the CCAC Guidelines Committee:

Dr Ernest Olfert, University of Saskatchewan (Co-chair)
Dr Jag Bhasin, National Research Council (Co-chair)
Dr Richard Latt, McGill University
Dr Eileen Macallum, Warner-Lambert Canada Inc.
Dr Kathie McCutcheon, University of Manitoba
Dr Don Rainnie, University of Prince Edward Island
Dr Michael Schunk, Pasteur Mérieux Connaught

The CCAC is also grateful to the many individuals, organizations and associations, that provided comments on earlier drafts of these guidelines.

1998

TABLE OF CONTENTS

INTRODUCTION

GENERAL GUIDELINE

Making the Appropriate Observations of the Animals

USING PRELIMINARY OR PILOT STUDIES TO DETERMINE THE APPROPRIATE ENDPOINT

DETERMINING THE REQUIRED FREQUENCY OF ANIMAL OBSERVATIONS

DEFINING RESPONSIBILITY FOR ANIMAL OBSERVATION

TRAINING OF PERSONNEL IN CLINICAL ANIMAL OBSERVATIONS

THE ROLE OF THE INSTITUTION'S ANIMAL CARE COMMITTEE IN SETTING ENDPOINTS

GUIDELINES FOR SELECTING APPROPRIATE ENDPOINTS IN SPECIFIC AREAS OF BIOMEDICAL RESEARCH AND TESTING

Monoclonal Antibody Production in Rodents

Cancer Research

Toxicological Studies and Toxicity Testing

Acute toxicity testing

Chronic toxicity studies and studies in aging

SUMMARY

REFERENCES

APPENDIX A - SPECIES SPECIFIC SIGNS OF PAIN AND/OR DISTRESS

APPENDIX B - SIGNS OF PAIN AND/OR DISTRESS IN FISH IN TOXICOLOGY

APPENDIX C - EXAMPLES OF OBSERVATIONAL CHECKLISTS USED TO DETERMINE ENDPOINTS

Hard copies of these or other CCAC guidelines can be ordered through the publications order form.

If you have any problems with accessing these guidelines, please contact Dr Gilly Griffin at ccac@ccac.ca.

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