Contact Us  |  Site Map  |  Français  
 
About CCAC
What's New
Programs
Publications
Committees
Contact
Links
Media

CCAC guidelines on: choosing an appropriate endpoint in experiments using animals for research, teaching and testing

To the Table of Contents  


The CCAC guidelines on: choosing an appropriate endpoint in experiments using animals for research, teaching and testing were developed by the ad hoc subcommittee on endpoints of the CCAC Guidelines Committee:

Dr Ernest Olfert, University of Saskatchewan (Co-chair)

Dr Jag Bhasin, National Research Council (Co-chair)

Dr Richard Latt, McGill University

Dr Eileen Macallum, Warner-Lambert Canada Inc.

Dr Kathie McCutcheon, University of Manitoba

Dr Don Rainnie, University of Prince Edward Island

Dr Michael Schunk, Pasteur Mérieux Connaught



The CCAC is also grateful to the many individuals, organizations and associations, that provided comments on earlier drafts of these guidelines.

1998





TABLE OF CONTENTS


  • INTRODUCTION


  • GENERAL GUIDELINE


  • RECOMMENDED PROCEDURES FOR SELECTING AN APPROPRIATE ENDPOINT

    1. Making the Appropriate Observations of the Animals

    2. Scoring of Significant Physiological Observations to Select and Refine Endpoints
    3. Identifying Significant Behavioral Indicators of Pain and/or Distress
  • USING PRELIMINARY OR PILOT STUDIES TO DETERMINE THE APPROPRIATE ENDPOINT


  • DETERMINING THE REQUIRED FREQUENCY OF ANIMAL OBSERVATIONS


  • DEFINING RESPONSIBILITY FOR ANIMAL OBSERVATION


  • TRAINING OF PERSONNEL IN CLINICAL ANIMAL OBSERVATIONS


  • THE ROLE OF THE INSTITUTION'S ANIMAL CARE COMMITTEE IN SETTING ENDPOINTS
  • GUIDELINES FOR SELECTING APPROPRIATE ENDPOINTS IN SPECIFIC AREAS OF BIOMEDICAL RESEARCH AND TESTING

    1. Monoclonal Antibody Production in Rodents

    2. Cancer Research

    3. Toxicological Studies and Toxicity Testing
      1. Acute toxicity testing

      2. Chronic toxicity studies and studies in aging
    4. Pain Research
    5. Infectious Disease Studies, Vaccine Trials, etc.
    6. Specific Animal Models with the Potential for Significant Levels of Pain and/or Distress
  • SUMMARY


  • REFERENCES


  • APPENDIX A - SPECIES SPECIFIC SIGNS OF PAIN AND/OR DISTRESS

    APPENDIX B - SIGNS OF PAIN AND/OR DISTRESS IN FISH IN TOXICOLOGY

    APPENDIX C - EXAMPLES OF OBSERVATIONAL CHECKLISTS USED TO DETERMINE ENDPOINTS

    Hard copies of these or other CCAC guidelines can be ordered through the publications order form.

    If you have any problems with accessing these guidelines, please contact Dr Gilly Griffin at ccac@ccac.ca.


    [ Back to top ]

    © 2005 CCAC, All Rights Reserved. | Privacy Statement | Design by Media Wave